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Luciano Adorini Selected Research

BXL628

4/2009The vitamin D receptor agonist elocalcitol inhibits IL-8-dependent benign prostatic hyperplasia stromal cell proliferation and inflammatory response by targeting the RhoA/Rho kinase and NF-kappaB pathways.
3/2007Inhibition of prostate growth and inflammation by the vitamin D receptor agonist BXL-628 (elocalcitol).
2/2007BXL-628, a vitamin D receptor agonist effective in benign prostatic hyperplasia treatment, prevents RhoA activation and inhibits RhoA/Rho kinase signaling in rat and human bladder.
12/2006Treatment of experimental autoimmune prostatitis in nonobese diabetic mice by the vitamin D receptor agonist elocalcitol.
6/2006The vitamin D analogue BXL-628 inhibits growth factor-stimulated proliferation and invasion of DU145 prostate cancer cells.
7/2005Inhibition of acute and chronic allograft rejection in mouse models by BXL-628, a nonhypercalcemic vitamin D receptor agonist.
2/2005Human bladder as a novel target for vitamin D receptor ligands.

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Luciano Adorini Research Topics

Disease

22Inflammation (Inflammations)
12/2019 - 12/2002
14Autoimmune Diseases (Autoimmune Disease)
05/2009 - 01/2002
13Fibrosis (Cirrhosis)
01/2020 - 12/2009
8Type 1 Diabetes Mellitus (Autoimmune Diabetes)
08/2011 - 05/2002
7Metabolic Syndrome (Dysmetabolic Syndrome X)
01/2018 - 01/2011
6Prostatic Hyperplasia (Benign Prostatic Hyperplasia)
07/2012 - 06/2006
5Biliary Liver Cirrhosis (Primary Biliary Cirrhosis)
01/2020 - 06/2009
5Insulin Resistance
12/2019 - 01/2013
5Non-alcoholic Fatty Liver Disease
01/2019 - 04/2013
5Atherosclerosis
10/2018 - 08/2011
5Proteinuria
01/2018 - 12/2009
5Prostatitis
09/2009 - 12/2006
4Type 2 Diabetes Mellitus (MODY)
01/2019 - 10/2010
4Obesity
01/2018 - 12/2009
4Hypogonadism (Hypergonadotropic Hypogonadism)
01/2014 - 07/2012
4Hypercalcemia (Milk Alkali Syndrome)
06/2010 - 05/2004
3Reperfusion Injury
04/2022 - 01/2018
3Dyslipidemias (Dyslipidemia)
01/2020 - 08/2011
3Disease Progression
01/2018 - 05/2002
3Diabetic Nephropathies (Diabetic Nephropathy)
01/2018 - 11/2010
3Hypoxia (Hypoxemia)
01/2017 - 01/2012
3Hyperglycemia
08/2011 - 11/2010
3Neoplasms (Cancer)
11/2008 - 01/2006
2Metabolic Diseases (Metabolic Disease)
06/2022 - 10/2010
2Fatty Liver
06/2022 - 11/2018
2Liver Diseases (Liver Disease)
06/2022 - 10/2010
2Ischemia
04/2022 - 01/2018
2Hypercholesterolemia
01/2018 - 01/2018
2Kidney Diseases (Kidney Disease)
01/2017 - 01/2016
2Glucose Intolerance
01/2014 - 01/2011
2Colitis
04/2011 - 06/2010
2Rheumatoid Arthritis
01/2011 - 11/2004
2Breast Neoplasms (Breast Cancer)
11/2008 - 03/2007
2Carcinogenesis
11/2008 - 03/2007
2Psoriasis (Pustulosis Palmaris et Plantaris)
07/2007 - 06/2002
2Prostatic Neoplasms (Prostate Cancer)
03/2007 - 06/2006
2Pelvic Pain
02/2007 - 12/2006
2Hyperplasia
07/2005 - 02/2005
1Alcoholic Fatty Liver
06/2022
1Cholestasis
11/2021
1Intrahepatic Cholestasis of Pregnancy
01/2020
1Hepatocellular Carcinoma (Hepatoma)
01/2020
1Hepatomegaly
12/2019

Drug/Important Bio-Agent (IBA)

18obeticholic acidIBA
04/2022 - 11/2010
14Calcitriol Receptors (Calcitriol Receptor)IBA
06/2010 - 06/2002
12Bile Acids and Salts (Bile Acids)IBA
06/2022 - 10/2010
106-ethyl-24-norcholane-3,7,23-triol-23 sulfateIBA
01/2020 - 10/2010
9LipidsIBA
12/2019 - 12/2009
9Insulin (Novolin)FDA Link
01/2018 - 01/2002
8LigandsIBA
06/2022 - 06/2002
76alpha-ethyl-23(S)-methylcholic acidIBA
06/2022 - 10/2011
7BXL628IBA
04/2009 - 02/2005
6Glucose (Dextrose)FDA LinkGeneric
06/2022 - 01/2011
6Messenger RNA (mRNA)IBA
01/2019 - 10/2002
5AcidsIBA
11/2018 - 12/2009
5Interleukin-6 (Interleukin 6)IBA
01/2017 - 04/2009
5Vitamin DFDA LinkGeneric
01/2011 - 08/2004
5Calcitriol (Calcijex)FDA LinkGeneric
07/2007 - 10/2002
4G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA
06/2022 - 10/2010
4EnzymesIBA
11/2021 - 11/2010
4Hormones (Hormone)IBA
11/2017 - 04/2002
4CytokinesIBA
01/2017 - 02/2007
4Testosterone (Sustanon)FDA Link
10/2012 - 01/2012
4Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
11/2010 - 06/2006
41,25-dihydroxyvitamin DIBA
06/2010 - 04/2002
4Interleukin-12 (IL 12)IBA
09/2009 - 05/2002
3Pharmaceutical PreparationsIBA
12/2019 - 01/2006
3Streptozocin (Streptozotocin)FDA Link
01/2018 - 11/2010
3Fatty Acids (Saturated Fatty Acids)IBA
01/2018 - 12/2009
3AndrogensIBA
07/2012 - 02/2005
3Interleukin-8 (Interleukin 8)IBA
01/2012 - 02/2007
3AutoantigensIBA
09/2009 - 05/2002
3rho-Associated KinasesIBA
04/2009 - 02/2007
3Peptides (Polypeptides)IBA
08/2007 - 05/2003
3ChemokinesIBA
02/2007 - 12/2002
2Matrix Metalloproteinases (MMPs)IBA
04/2022 - 01/2020
2Glucagon-Like Peptide 1 (GLP 1)IBA
01/2019 - 10/2010
2Proteins (Proteins, Gene)FDA Link
11/2018 - 02/2005
2Cholic AcidIBA
10/2018 - 07/2014
2Ursodeoxycholic Acid (Urso)FDA LinkGeneric
01/2018 - 04/2015
2MonocrotalineIBA
11/2017 - 01/2017
2Bleomycin (Blenoxane)FDA LinkGeneric
11/2017 - 01/2017
2SteroidsIBA
11/2017 - 12/2006
2Alanine Transaminase (SGPT)IBA
04/2015 - 09/2013
2Gonadotropin-Releasing Hormone (GnRH)FDA Link
01/2014 - 10/2012
2Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA
08/2011 - 10/2010
2Dextrans (Dextran)FDA Link
04/2011 - 06/2010
2sodium sulfate (sodium bisulfate)FDA LinkGeneric
04/2011 - 06/2010
2NF-kappa B (NF-kB)IBA
04/2009 - 08/2004
2Cholecalciferol (Vitamin D3)FDA Link
11/2008 - 01/2006
2AntigensIBA
08/2005 - 11/2004
11- (4- (3- (hydroxyimino)- 3- (2- methylpyridin- 4- yl)- 1- o- tolylpropyl)phenyl)piperidine- 4- carboxylic acidIBA
06/2022
1ProgesteroneFDA LinkGeneric
11/2021
1Antifibrotic AgentsIBA
01/2020
1Nonesterified Fatty Acids (NEFA)IBA
01/2020
1Galectin 3 (LGALS3)IBA
12/2019
1Hematoxylin (Haematoxylon)IBA
12/2019
1Eosine Yellowish-(YS) (Eosin)IBA
12/2019
1LiraglutideFDA Link
12/2019

Therapy/Procedure

5Therapeutics
06/2022 - 02/2005